Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma

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Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma: Report of a Case and Review of the Literature

Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and during acute lymphoblastic leukemia therapy due to oral 6-thioguanine. However, its occurrence in the context of ch...

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Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or “blue liver syndrome”, is a commonly recognized vascular pattern of drug-induced liver injury, and has been frequently associated wit...

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Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma

Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemother...

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Biomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepatic sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is one of the major complications during the early period after hematopoietic cell transplantation (HCT). The disease is caused by toxic injury of conditioning therapy...

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Hepatic sinusoidal obstruction syndrome following hematopoietic stem cell transplantation.

J.m., a 43-year-old man with acute myelogenous leukemia with a monosomy 7 cytogenetic abnormality, received an allogeneic hematopoietic stem cell transplantation (HscT) from his human leukocyte antigen– matched brother. Past treatments included idarubicin and cytarabine induction therapy followed by a cycle of high-dose cytarabine. J.m. was in complete remission prior to the HscT. The condition...

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ژورنال

عنوان ژورنال: Journal of Pediatric Hematology/Oncology

سال: 2014

ISSN: 1077-4114

DOI: 10.1097/mph.0b013e3182a8f352